hERG (human ether-a-go-go related gene) is essential to the maintenance of a normal cardiac function. hERG encodes the pore-forming subunit of the ion channel that conducts the rapid component of the delayed rectifier potassium current (IKr) in the heart.
Mutations in hERG, or drug-induced blockade of hERG, may result in increase susceptibility to QT-interval prolongation, leading to ventricular tachycardia and sudden cardiac death.
In this context, recommendations from the International Conference on Harmonization (ICH) guidelines indicate a golden standard for the assessment of toxicity of drug candidates: the test for hERG interaction by means of patch-clamp studies.
Such assays need efficient cellular tools, that's why, for more than 5 years, CreaCell provides high performance cell lines stably expressing the hERG potassium channel.
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